Ultime
notizie :: RISULTATI DI UNO STUDIO
SULL’USO DEI RIMEDI OMEOAPTICI
PER LA CURA DEL TUMORE AL SENO
Cytotoxic effects of ultra-diluted
remedies on breast cancer cells
Authors: Moshe Frenkel, Bal Mukund
Mishra, Subrata Sen, Peiying Yang,
Alison Pawlus, Luis Vence, Aimee Leblanc,
Lorenzo Cohen, Pratip Banerji, Prasanta
Banerji
Affiliations: Integrative Medicine
Program-Unit 145, The University of
Texas M.D. Anderson Cancer Center,
Houston, TX 77030-4009, USA. [email protected]
Pages: 395-403
Abstract:
The use of ultra-diluted natural products
in the management of disease and treatment
of cancer has generated a lot of interest
and controversy. We conducted an in
vitro study to determine if products
prescribed by a clinic in India have
any effect on breast cancer cell lines.
We studied four ultra-diluted remedies
(Carcinosin, Phytolacca, Conium and
Thuja) against two human breast adenocarcinoma
cell lines (MCF-7 and MDA-MB-231)
and a cell line derived from immortalized
normal human mammary epithelial cells
(HMLE). The remedies exerted preferential
cytotoxic effects against the two
breast cancer cell lines, causing
cell cycle delay/arrest and apoptosis.
These effects were accompanied by
altered expression of the cell cycle
regulatory proteins, including downregulation
of phosphorylated Rb and upregulation
of the CDK inhibitor p27, which were
likely responsible for the cell cycle
delay/arrest as well as induction
of the apoptotic cascade that manifested
in the activation of caspase 7 and
cleavage of PARP in the treated cells.
The findings demonstrate biological
activity of these natural products
when presented at ultra-diluted doses.
Further in-depth studies with additional
cell lines and animal models are warranted
to explore the clinical applicability
of these agents.
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